{"term":{"id":"08437","title":"transverse relaxation optimized spectroscopy","longtitle":"IUPAC Gold Book - transverse relaxation optimized spectroscopy","doi":"10.1351\/goldbook.08437","code":"08437","status":"current","initialism":"<em>initialism<\/em>: TROSY","definitions":[{"id":1,"text":"Measurement method of nuclear magnetic resonance spectroscopy, usually in protein NMR, that improves peak sharpness for molecules having a molecular mass of greater than \\(\\pu{100 kDa}\\).","notes":{"1":"TROSY relies on the cancellation of the dipolar coupling and chemical shift anisotropy (CSA) components of the transverse relaxation (see spin-spin relaxation)."},"links":[{"term":"chemical shift anisotropy","url":"https:\/\/goldbook.iupac.org\/terms\/view\/08320"},{"term":"nuclear magnetic resonance spectroscopy","url":"https:\/\/goldbook.iupac.org\/terms\/view\/08218"},{"term":"spin-spin relaxation","url":"https:\/\/goldbook.iupac.org\/terms\/view\/08425"}],"sources":["PAC, 2021, 93, 647. 'Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)' on page 709 (https:\/\/doi.org\/10.1515\/pac-2019-0203)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/08437\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/08437\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/08437\/plain"},"citation":"Citation: 'transverse relaxation optimized spectroscopy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.08437","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-06-30T19:03:09+00:00"}}