Title: transverse relaxation optimized spectroscopy
Long Title: IUPAC Gold Book - transverse relaxation optimized spectroscopy
DOI: 10.1351/goldbook.08437
Status: current

Definition
Measurement method of nuclear magnetic resonance spectroscopy, usually in protein NMR, that improves peak sharpness for molecules having a molecular mass of greater than \(\pu{100 kDa}\).

Note
TROSY relies on the cancellation of the dipolar coupling and chemical shift anisotropy (CSA) components of the transverse relaxation (see spin-spin relaxation).

Related Terms
- chemical shift anisotropy: https://goldbook.iupac.org/terms/view/08320
- nuclear magnetic resonance spectroscopy: https://goldbook.iupac.org/terms/view/08218
- spin-spin relaxation: https://goldbook.iupac.org/terms/view/08425

Source
- PAC, 2021, 93, 647. 'Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)' on page 709 (https://doi.org/10.1515/pac-2019-0203)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/08437/html
- json: https://goldbook.iupac.org/terms/view/08437/json
- xml: https://goldbook.iupac.org/terms/view/08437/xml

Citation: Citation: 'transverse relaxation optimized spectroscopy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.08437
License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.
Collection: If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .
Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-06-30T19:04:09+00:00