09859 IUPAC Gold Book - signalling lipids 10.1351/goldbook.09859 09859 current synonym: lipid mediators 1 Lipid molecules involved in intracellular signalling and the regulation of cell death, immune response, or inflammation. Signalling lipids include diacylglycerol, phosphatidic acid, phosphatidylinositol-4,5-bisphosphate (the source of polyphosphorylated inositols), arachidonic acid-derived mediators (icosanoids, prostaglandins and leukotrienes), sphingolipid-derived mediators (ceramides, sphingosine, sphingosine-1-phosphate), or cholesterol-derived steroid hormones (androgens, estrogens, progestogens, mineralocorticoids, glucocorticoids). Broadly defined term referring to any lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediates the effects of these lipids on specific cellular responses. PAC, 2018, 90, 1121. 'Terminology of bioanalytical methods (IUPAC Recommendations 2018)' on page 1181 (https://doi.org/10.1515/pac-2016-1120) https://goldbook.iupac.org/terms/view/09859/html https://goldbook.iupac.org/terms/view/09859/json https://goldbook.iupac.org/terms/view/09859/plain Citation: 'signalling lipids' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09859 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-06-28T09:04:54+00:00