{"term":{"id":"10469","title":"bone morphogenetic protein-4","longtitle":"IUPAC Gold Book - bone morphogenetic protein-4","doi":"10.1351\/goldbook.10469","code":"10469","status":"current","initialism":"<em>initialism<\/em>: BMP4","synonym":"<em>synonym<\/em>: bone morphogenic protein-4 (BMP4)","definitions":[{"id":1,"text":"Bone morphogenetic protein member of the transforming growth factor \\(\\upbeta\\) (TGF-\\(\\upbeta\\)) superfamily.","notes":{"1":"Amongst the multiple functions of BMP4 is a role in early embryonic differentiation, where it is secreted from the notochord and acts with sonic hedgehog protein to establish a dorsal-ventral axis."},"links":[{"term":"Bone morphogenetic protein","url":"https:\/\/goldbook.iupac.org\/terms\/view\/10468"},{"term":"Spemann organizer","url":"https:\/\/goldbook.iupac.org\/terms\/view\/11235"},{"term":"dorsal","url":"https:\/\/goldbook.iupac.org\/terms\/view\/10615"},{"term":"notochord","url":"https:\/\/goldbook.iupac.org\/terms\/view\/11021"},{"term":"sonic hedgehog","url":"https:\/\/goldbook.iupac.org\/terms\/view\/11232"},{"term":"ventral","url":"https:\/\/goldbook.iupac.org\/terms\/view\/11363"}],"sources":["PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 731 (https:\/\/doi.org\/10.1515\/pac-2015-1202)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/10469\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/10469\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/10469\/plain"},"citation":"Citation: 'bone morphogenetic protein-4' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.10469","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-15T11:48:06+00:00"}}