Title: bone morphogenetic protein-4
Long Title: IUPAC Gold Book - bone morphogenetic protein-4
DOI: 10.1351/goldbook.10469
Status: current

Definition
Bone morphogenetic protein member of the transforming growth factor \(\upbeta\) (TGF-\(\upbeta\)) superfamily.

Note
Amongst the multiple functions of BMP4 is a role in early embryonic differentiation, where it is secreted from the notochord and acts with sonic hedgehog protein to establish a dorsal-ventral axis.

Related Terms
- Bone morphogenetic protein: https://goldbook.iupac.org/terms/view/10468
- Spemann organizer: https://goldbook.iupac.org/terms/view/11235
- dorsal: https://goldbook.iupac.org/terms/view/10615
- notochord: https://goldbook.iupac.org/terms/view/11021
- sonic hedgehog: https://goldbook.iupac.org/terms/view/11232
- ventral: https://goldbook.iupac.org/terms/view/11363

Source
- PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 731 (https://doi.org/10.1515/pac-2015-1202)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/10469/html
- json: https://goldbook.iupac.org/terms/view/10469/json
- xml: https://goldbook.iupac.org/terms/view/10469/xml

Citation: Citation: 'bone morphogenetic protein-4' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10469
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-05-15T11:50:08+00:00