10803 IUPAC Gold Book - holoprosencephaly 10.1351/goldbook.10803 10803 current synonym: arhinencephaly 1 Birth defect in which the embryonic forebrain fails to divide completely to form the cerebral hemispheres. This results in varying degrees of mental impairment and abnormal development of eye, nose, and lip. cerebral hemispheres https://goldbook.iupac.org/terms/view/10504 forebrain https://goldbook.iupac.org/terms/view/11144 PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 764 (https://doi.org/10.1515/pac-2015-1202) https://goldbook.iupac.org/terms/view/10803/html https://goldbook.iupac.org/terms/view/10803/json https://goldbook.iupac.org/terms/view/10803/plain Citation: 'holoprosencephaly' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10803 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-05-14T20:47:33+00:00