{"term":{"id":"11017","title":"nodal","longtitle":"IUPAC Gold Book - nodal","doi":"10.1351\/goldbook.11017","code":"11017","status":"current","synonym":"<em>synonym<\/em>: nodal protein","definitions":[{"id":1,"text":"Growth factor of the transforming growth factor \\(\\upbeta\\) (TGF-\\(\\upbeta\\)) superfamily, coded by a gene designated NODAL, that plays crucial roles in embryogenesis, particularly in signalling from the primitive streak to the mesoderm to establish left-right asymmetry as well as aspects of stem cell differentiation.","notes":{"1":"The name derives from expression of the gene in the primitive node."},"links":[{"term":"Growth factor","url":"https:\/\/goldbook.iupac.org\/terms\/view\/10782"},{"term":"embryogenesis","url":"https:\/\/goldbook.iupac.org\/terms\/view\/10644"},{"term":"mesoderm","url":"https:\/\/goldbook.iupac.org\/terms\/view\/10944"},{"term":"primitive node","url":"https:\/\/goldbook.iupac.org\/terms\/view\/11129"},{"term":"primitive streak","url":"https:\/\/goldbook.iupac.org\/terms\/view\/11131"}],"sources":["PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 785 (https:\/\/doi.org\/10.1515\/pac-2015-1202)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/11017\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/11017\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/11017\/plain"},"citation":"Citation: 'nodal' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.11017","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-11T02:09:23+00:00"}}