Title: one-generation reprotox study
Long Title: IUPAC Gold Book - one-generation reprotox study
DOI: 10.1351/goldbook.11039
Status: current

Definition
Procedure in which male rodents are dosed with a test substance for at least one spermatogenic cycle, and females for two estrous cycles, and then further exposed during mating, pregnancy, and nursing; adverse effects on reproduction, parturition, lactation and postnatal growth are studied.

Related Terms
- estrous cycles: https://goldbook.iupac.org/terms/view/10684
- lactation: https://goldbook.iupac.org/terms/view/10881
- parturition: https://goldbook.iupac.org/terms/view/11075
- postnatal: https://goldbook.iupac.org/terms/view/11111
- pregnancy: https://goldbook.iupac.org/terms/view/11116
- spermatogenic: https://goldbook.iupac.org/terms/view/11240
- two-generation reprotox study: https://goldbook.iupac.org/terms/view/11334

Source
- PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 787 (https://doi.org/10.1515/pac-2015-1202)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/11039/html
- json: https://goldbook.iupac.org/terms/view/11039/json
- xml: https://goldbook.iupac.org/terms/view/11039/xml

Citation: Citation: 'one-generation reprotox study' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11039
License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-07-26T22:51:20+00:00