11165 IUPAC Gold Book - reciprocal mesenchymal-epithelial interaction 10.1351/goldbook.11165 11165 current 1 Process in tissue or organ development in which epithelium induces changes in the mesenchyme and the mesenchyme also induces changes in the epithelium, through paracrine signaling. An example occurs during development of the prostate, in which mesenchyme of the urogenital sinus influences differentiation and patterning of the prostatic epithelium, and the developing epithelium induces prostatic mesenchymal cells to differentiate into smooth muscle and other prostatic stromal cells. epithelial-to-mesenchymal transition https://goldbook.iupac.org/terms/view/10675 epithelium https://goldbook.iupac.org/terms/view/10674 mesenchymal-to-epithelial transition https://goldbook.iupac.org/terms/view/10941 mesenchyme https://goldbook.iupac.org/terms/view/10942 paracrine https://goldbook.iupac.org/terms/view/11065 prostate https://goldbook.iupac.org/terms/view/11145 stromal cells https://goldbook.iupac.org/terms/view/11264 urogenital sinus https://goldbook.iupac.org/terms/view/11345 PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 799 (https://doi.org/10.1515/pac-2015-1202) https://goldbook.iupac.org/terms/view/11165/html https://goldbook.iupac.org/terms/view/11165/json https://goldbook.iupac.org/terms/view/11165/plain Citation: 'reciprocal mesenchymal-epithelial interaction' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11165 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-05-15T09:55:54+00:00