11232 IUPAC Gold Book - sonic hedgehog 10.1351/goldbook.11232 11232 current 1 Protein morphogen produced in the notochord that plays a critical role in early development, including vertebrate organogenesis, brain development and limb formation. Production in the embryo is dependent upon secretion of fibroblast growth factors. bone morphogenetic protein-4 https://goldbook.iupac.org/terms/view/10469 fibroblast growth factors https://goldbook.iupac.org/terms/view/10720 morphogen https://goldbook.iupac.org/terms/view/10972 notochord https://goldbook.iupac.org/terms/view/11021 organogenesis https://goldbook.iupac.org/terms/view/11048 vertebrate https://goldbook.iupac.org/terms/view/11367 PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 806 (https://doi.org/10.1515/pac-2015-1202) https://goldbook.iupac.org/terms/view/11232/html https://goldbook.iupac.org/terms/view/11232/json https://goldbook.iupac.org/terms/view/11232/plain Citation: 'sonic hedgehog' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11232 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-05-15T10:55:39+00:00