11297 IUPAC Gold Book - tetralogy of Fallot 10.1351/goldbook.11297 11297 current 1 Set of four congenital cardiac defects involving an opening in the wall that should separate the right and left ventricles (ventricular septal defect), allowing the aorta to receive venous as well as arterial blood: including stenosis of the pulmonary artery, hypertrophy of the right ventricle, and displacement of the aorta. Right ventricular hypertrophy is the fourth part of the tetralogy, although it may also be a consequence of the other defects. The constellation of anatomical defects is understandable in terms of a flaw in the ordered sequence of events in the normal development of the heart and associated vessels. These anatomical defects are the most common cardiac cause of cyanosis in infants. aorta https://goldbook.iupac.org/terms/view/10416 cardiac https://goldbook.iupac.org/terms/view/10489 congenital https://goldbook.iupac.org/terms/view/10552 cyanosis https://goldbook.iupac.org/terms/view/10579 hypertrophy https://goldbook.iupac.org/terms/view/10828 pulmonary artery https://goldbook.iupac.org/terms/view/11157 stenosis https://goldbook.iupac.org/terms/view/11256 ventricular septal defect https://goldbook.iupac.org/terms/view/11365 PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 812 (https://doi.org/10.1515/pac-2015-1202) https://goldbook.iupac.org/terms/view/11297/html https://goldbook.iupac.org/terms/view/11297/json https://goldbook.iupac.org/terms/view/11297/plain Citation: 'tetralogy of Fallot' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11297 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-05-15T04:02:20+00:00