Title: trisomy 8
Long Title: IUPAC Gold Book - trisomy 8
DOI: 10.1351/goldbook.11322
Status: current

Definition
Presence of an extra chromosome 8.

Note
Complete trisomy 8 is lethal, but most affected individuals show mosaicism with craniofacial abnormalities, a short wide neck, multiple joint defects, and deep creases in the palms and soles.

Related Terms
- craniofacial: https://goldbook.iupac.org/terms/view/10565
- mosaicism: https://goldbook.iupac.org/terms/view/10976
- trisomy: https://goldbook.iupac.org/terms/view/11321

Source
- PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 815 (https://doi.org/10.1515/pac-2015-1202)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/11322/html
- json: https://goldbook.iupac.org/terms/view/11322/json
- xml: https://goldbook.iupac.org/terms/view/11322/xml

Citation: Citation: 'trisomy 8' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11322
License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.
Collection: If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .
Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-06-13T21:31:26+00:00