Title: Wnt
Long Title: IUPAC Gold Book - Wnt
DOI: 10.1351/goldbook.11384
Status: current

Definition
Family of genes important in development, the proteins they encode, or the signal transduction pathways they determine.

Notes
1) Wnt pathways are involved throughout embryonic development, regulating such processes as cytoskeletal dynamics, cell polarity, proliferation, migration, and body axis patterning.
2) The proteins signal by binding to cell-surface G-protein coupled receptors of the Frizzled family that signal to members of the Dishevelled (Dsh) family of cytoplasmic phosphoproteins.
3) Wnt is derived from Wingless-related integration site, originally identified in Drosophila.

Related Term
- signal transduction: https://goldbook.iupac.org/terms/view/11219

Source
- PAC, 2016, 88, 713. 'Glossary of terms used in developmental and reproductive toxicology (IUPAC Recommendations 2016)' on page 821 (https://doi.org/10.1515/pac-2015-1202)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/11384/html
- json: https://goldbook.iupac.org/terms/view/11384/json
- xml: https://goldbook.iupac.org/terms/view/11384/xml

Citation: Citation: 'Wnt' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11384
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Accessed: 2026-05-11T03:08:36+00:00