glutamate-induced excitotoxicity

https://doi.org/10.1351/goldbook.11793
Form of excitotoxicity where excess glutamate release in synapses (glutamatergic storm) leads to overstimulation, followed by excess cellular calcium uptake, cytotoxicity and apoptosis.
Notes:
  1. N-methyl-D-aspartic acid, kainic acid, and other ligands of the glutamate receptor induce this effect.
  2. Excitotoxicity may occur after acute neuronalischemia and damage. It is believed to be a factor in chronic diseases of the nervous system, and in some withdrawal phenomena.
Source:
PAC, 2015, 87, 841. (IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)) on page 871 [Terms] [Paper]
Citation: 'glutamate-induced excitotoxicity' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.11793 RIS BibTex EndNote
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