misfolded protein

https://doi.org/10.1351/goldbook.11878
Protein that has the same amino acid sequence as the normal, functional protein but exhibits a deviant tertiary structure and lacks normal function.
Note: Common neurodegenerative diseases (e.g., Alzheimer disease) are associated with the formation, aggregation and deposition of misfolded proteins in neurons.
See also: inclusion body
Source:
PAC, 2015, 87, 841. (IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)) on page 882 [Terms] [Paper]
Citation: 'misfolded protein' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.11878 RIS BibTex EndNote
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