https://doi.org/10.1351/goldbook.12124
- Adverse responsiveness to heat or cold.
Note: It is associated with a number of medical conditions, some physiologically well-defined (as in cold intolerance in hypothyroidism) and others less so (as in reported chronic fatigue syndrome). - Phenotype arising from engineered or selected gene mutations in experimental organisms characterized by an altered temperature permissive for optimal growth or survival.