Title: tetrodotoxin-insensitive
Long Title: IUPAC Gold Book - tetrodotoxin-insensitive
DOI: 10.1351/goldbook.12134
Status: current

Definition
Denoting a class of sodium ion channels, found mainly in the heart, that is not blocked by tetrodotoxin.

Note
Their significance lies in experimental characterization of channel subtypes in neuromuscular physiology, development, and drug design.

Related Terms
- ion channels: https://goldbook.iupac.org/terms/view/11838
- tetrodotoxin: https://goldbook.iupac.org/terms/view/12133

Source
- PAC, 2015, 87, 841. 'IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)' on page 911 (https://doi.org/10.1515/pac-2015-0103)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/12134/html
- json: https://goldbook.iupac.org/terms/view/12134/json
- xml: https://goldbook.iupac.org/terms/view/12134/xml

Citation: Citation: 'tetrodotoxin-insensitive' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12134
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-05-10T12:23:36+00:00