back-up compound

https://doi.org/10.1351/goldbook.12623
Molecule selected as a replacement for the lead drug candidate should this subsequently fail during further preclinical evaluation or in clinical studies.
Note: Ideally, a back-up should be pharmacologically equivalent to the lead drug but have significant structural differences. Possession of a distinct core scaffold is optimal.
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1728 [Terms] [Paper]
Citation: 'back-up compound' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12623 RIS BibTex EndNote
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