covalent drug

https://doi.org/10.1351/goldbook.12640
Ligand that binds irreversibly to its molecular target through the formation of a new chemical bond.
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1731 [Terms] [Paper]