{"term":{"id":"12649","title":"drug safety","longtitle":"IUPAC Gold Book - drug safety","doi":"10.1351\/goldbook.12649","code":"12649","status":"current","definitions":[{"id":1,"text":"Assessment of the nontolerable biological effects of a drug.","notes":{"1":"Because the nontolerable effects of a drug are directly related to its concentration or dose, safety is generally ranked relative to the dose required to obtain the desirable effect."},"links":[{"term":"therapeutic index","url":"https:\/\/goldbook.iupac.org\/terms\/view\/12735"}],"sources":["PAC, 2013, 85, 1725. 'Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)' on page 1733 (https:\/\/doi.org\/10.1351\/PAC-REC-12-11-23)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/12649\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/12649\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/12649\/plain"},"citation":"Citation: 'drug safety' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.12649","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-06-27T11:15:31+00:00"}}