hit-to-lead chemistry

https://doi.org/10.1351/goldbook.12666
Process by which a proven molecule or series derived from high-throughput screening or primary screens is chemically optimised to a viable lead or series.
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1737 [Terms] [Paper]
Citation: 'hit-to-lead chemistry' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12666 RIS BibTex EndNote
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