inhibitory concentration at 50%

symbol: $\pu{IC_{50}}$
https://doi.org/10.1351/goldbook.12669
The concentration of an enzyme inhibitor or receptor antagonist that reduces the enzyme activity or agonist response by \(\pu{50\%}\).
Note: \(\pu{IC_{50}}\) values are influenced by experimental conditions (e.g., substrate or agonist concentration, which should be specified).
See: inhibition constant
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1737 [Terms] [Paper]
Citation: 'inhibitory concentration at 50%' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12669 RIS BibTex EndNote
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