phase I clinical studies

https://doi.org/10.1351/goldbook.12708
Initial introduction of an investigational new drug into humans.
Note: These studies are designed to determine the metabolic and pharmacologic actions of the drug in humans, the side-effects associated with increasing doses, and, if possible, to gain early evidence on effectiveness.
See also: phase II, phase III, phase IV
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1746 [Terms] [Paper]
Citation: 'phase I clinical studies' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12708 RIS BibTex EndNote
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