target validation

https://doi.org/10.1351/goldbook.12733
Process by which a protein, RNA, or DNA is implicated in a biological pathway thought to be of relevance to a disease or adverse pathology.
Note: Typically, validation will involve location of the molecular target in relevant cells, organs, or tissues, evidence for its up-regulation/activation in the disorder, and the ability to attenuate adverse responses by agents known to interfere with the target.
Source:
PAC, 2013, 85, 1725. (Glossary of terms used in medicinal chemistry. Part II (IUPAC Recommendations 2013)) on page 1752 [Terms] [Paper]
Citation: 'target validation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12733 RIS BibTex EndNote
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