Title: ABL oncogene
Long Title: IUPAC Gold Book - ABL oncogene
DOI: 10.1351/goldbook.12827
Status: current

Definition
Gene resulting from a chromosomal translocation (9;22) that fuses sequences from the BCR (breakpoint cluster region) gene with the ABL gene.

Notes
1) This translocation creates the Philadelphia chromosome, found in most human patients with chronic myelogenous leukemia (CML).
2) The fusion protein encoded by BCR-ABL possesses unregulated tyrosine kinase activity.
3) The term ABL derives from the Abelson murine leukemia virus, from which the gene was first isolated.

Related Terms
- Philadelphia chromosome: https://goldbook.iupac.org/terms/view/13565
- chronic myelogenous leukemia (CML): https://goldbook.iupac.org/terms/view/13008
- tyrosine kinase: https://goldbook.iupac.org/terms/view/13766

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1115 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/12827/html
- json: https://goldbook.iupac.org/terms/view/12827/json
- xml: https://goldbook.iupac.org/terms/view/12827/xml

Citation: Citation: 'ABL oncogene' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12827
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Accessed: 2026-05-10T16:52:27+00:00