{"term":{"id":"12876","title":"angioedema","longtitle":"IUPAC Gold Book - angioedema","doi":"10.1351\/goldbook.12876","code":"12876","status":"current","initialism":"<em>initialisms<\/em>: AAE, HAE","mentioned":"<em>mentioned<\/em>: acquired angioedema, hereditary angioedema","synonym":"<em>synonym<\/em>: angioneurotic edema","definitions":[{"id":1,"text":"Swelling that occurs in the tissue just below the surface of the skin, most often around the lips and eyes, the mucous membranes and occasionally the viscera.","notes":{"1":"It may be genetic, when it is referred to as hereditary angioedema (HAE), but is more usually caused by an allergic reaction to either food or medication, and is then called acquired angioedema (AAE).","2":"Angioedema may take from minutes to hours to develop. Severe angioedema can compromise the airway, and can be life-threatening.","3":"Angioedema is often associated with dermatographism, urticaria, erythema, and purpura. It may sometimes be a sign of a condition such as leukemia or Hodgkin disease.","4":"Angioedema is similar to hives, but hives involve itchy red welts on the surface of the skin, whereas angioedema is a deeper swelling under the skin."},"links":[{"term":"Hodgkin disease","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13220"},{"term":"allergic","url":"https:\/\/goldbook.iupac.org\/terms\/view\/12858"},{"term":"erythema","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13125"},{"term":"hives","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13219"},{"term":"leukemia","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13378"},{"term":"purpura","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13625"}],"sources":["PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1123 (https:\/\/doi.org\/10.1351\/PAC-REC-11-06-03)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/12876\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/12876\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/12876\/plain"},"citation":"Citation: 'angioedema' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.12876","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-10T16:46:34+00:00"}}