12902 IUPAC Gold Book - aplastic anemia 10.1351/goldbook.12902 12902 current 1 Greatly decreased formation of erythrocytes and hemoglobin, usually associated with pronounced granulocytopenia and thrombocytopenia, as a result of hypoplastic or aplastic bone marrow. The diagnosis requires bone marrow biopsy to demonstrate replacement of blood cell precursors with fat cells and rule out other causes of pancytopenia such as neoplastic infiltration. bone marrow https://goldbook.iupac.org/terms/view/12959 erythrocytes https://goldbook.iupac.org/terms/view/13127 granulocytopenia https://goldbook.iupac.org/terms/view/13184 pancytopenia https://goldbook.iupac.org/terms/view/13532 PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1127 (https://doi.org/10.1351/PAC-REC-11-06-03) https://goldbook.iupac.org/terms/view/12902/html https://goldbook.iupac.org/terms/view/12902/json https://goldbook.iupac.org/terms/view/12902/plain Citation: 'aplastic anemia' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12902 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-07-25T13:39:48+00:00