{"term":{"id":"12932","title":"B-1\/B-2 cells","longtitle":"IUPAC Gold Book - B-1\/B-2 cells","doi":"10.1351\/goldbook.12932","code":"12932","status":"current","synonym":"<em>synonym<\/em>: B-1\/B-2 lymphocytes","definitions":[{"id":1,"text":"Two major subpopulations of B lymphocytes.","notes":{"1":"The majority of B cells are B-2 which express low levels of surface IgM, higher levels of surface IgD, do not express CD5, and are CD43-, CD23+; they are directly generated from precursors in the bone marrow, and secrete highly specific antibody.","2":"B-1 cells bear high levels of surface immunoglobulin M (IgM), show lower levels of surface immunoglobulin D (IgD), are CD43+\/CD23-, and most express the cell surface antigen CD5. They are self-renewing, and frequently secrete high levels of antibody that binds to a range of antigens (\"polyspecificity\") with a relatively low affinity."},"links":[{"term":"B lymphocytes","url":"https:\/\/goldbook.iupac.org\/terms\/view\/12937"},{"term":"CD23-","url":"https:\/\/goldbook.iupac.org\/terms\/view\/12979"},{"term":"bone marrow","url":"https:\/\/goldbook.iupac.org\/terms\/view\/12959"},{"term":"immunoglobulin D (IgD)","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13287"},{"term":"immunoglobulin M (IgM)","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13293"}],"sources":["PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1132 (https:\/\/doi.org\/10.1351\/PAC-REC-11-06-03)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/12932\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/12932\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/12932\/plain"},"citation":"Citation: 'B-1\/B-2 cells' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.12932","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-06-30T08:26:31+00:00"}}