Title: CD4+/CD25+ T cell
Long Title: IUPAC Gold Book - CD4+/CD25+ T cell
DOI: 10.1351/goldbook.12974
Status: current

Definition
Subtype of CD4+ regulatory T cell (Treg) with potential role in the regulation of immune homeostasis.

Notes
1) These cells seem to be important in preventing the development of autoimmune diseases (depletion leads to the spontaneous development of various autoimmune diseases in genetically susceptible animals; transfer prevents the development of organ-specific autoimmunity).
2) Activated T cells may also have this phenotype. Treg cells may be further distinguished by positivity for a protein marker Foxp3.

Related Terms
- Activated: https://goldbook.iupac.org/terms/view/13401
- CD4: https://goldbook.iupac.org/terms/view/12973
- Foxp3: https://goldbook.iupac.org/terms/view/13141
- T cells: https://goldbook.iupac.org/terms/view/13724
- autoimmune diseases: https://goldbook.iupac.org/terms/view/12919
- autoimmunity: https://goldbook.iupac.org/terms/view/12925
- immune: https://goldbook.iupac.org/terms/view/13272
- regulatory T cell (Treg): https://goldbook.iupac.org/terms/view/13644

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1138 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/12974/html
- json: https://goldbook.iupac.org/terms/view/12974/json
- xml: https://goldbook.iupac.org/terms/view/12974/xml

Citation: Citation: 'CD4+/CD25+ T cell' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12974
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Accessed: 2026-05-10T17:51:32+00:00