12996 IUPAC Gold Book - central tolerance 10.1351/goldbook.12996 12996 current 1 Specific immunological tolerance due to the induction of lymphocyte apoptosis or anergy within the primary lymphoid organs (bone marrow in the case of B cell tolerance and the thymus for T cells). B cell https://goldbook.iupac.org/terms/view/12937 T cells https://goldbook.iupac.org/terms/view/13724 anergy https://goldbook.iupac.org/terms/view/12875 bone marrow https://goldbook.iupac.org/terms/view/12959 lymphocyte https://goldbook.iupac.org/terms/view/13399 tolerance https://goldbook.iupac.org/terms/view/13302 PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1142 (https://doi.org/10.1351/PAC-REC-11-06-03) https://goldbook.iupac.org/terms/view/12996/html https://goldbook.iupac.org/terms/view/12996/json https://goldbook.iupac.org/terms/view/12996/plain Citation: 'central tolerance' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12996 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-05-10T02:14:16+00:00