Title: chronic rejection
Long Title: IUPAC Gold Book - chronic rejection
DOI: 10.1351/goldbook.13009
Status: current

Definition
Immunologically triggered reaction occurring in a transplanted organ or tissue, leading to progressive destruction and finally failure of the transplanted organ occurring two months to many years after transplantation.

Note
In contrast, hyperacute rejection caused by preformed antibodies starts within minutes after organ transplantation, and acute rejection occurs within 2 to 60 days.

Related Term
- transplantation: https://goldbook.iupac.org/terms/view/13754

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1144 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13009/html
- json: https://goldbook.iupac.org/terms/view/13009/json
- xml: https://goldbook.iupac.org/terms/view/13009/xml

Citation: Citation: 'chronic rejection' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13009
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Accessed: 2026-05-10T02:27:31+00:00