<?xml version="1.0" encoding="UTF-8"?>
<term>
  <id>13009</id>
  <title>chronic rejection</title>
  <longtitle>IUPAC Gold Book - chronic rejection</longtitle>
  <doi>10.1351/goldbook.13009</doi>
  <code>13009</code>
  <status>current</status>
  <synonym><em>synonym</em>: chronic graft rejection</synonym>
  <definitions>
    <item>
      <id>1</id>
      <text>Immunologically triggered reaction occurring in a transplanted organ or tissue, leading to progressive destruction and finally failure of the transplanted organ occurring two months to many years after transplantation.</text>
      <notes>
        <item>In contrast, hyperacute rejection caused by preformed antibodies starts within minutes after organ transplantation, and acute rejection occurs within 2 to 60 days.</item>
      </notes>
      <links>
        <item>
          <term>transplantation</term>
          <url>https://goldbook.iupac.org/terms/view/13754</url>
        </item>
      </links>
      <sources>
        <item>PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1144 (https://doi.org/10.1351/PAC-REC-11-06-03)</item>
      </sources>
    </item>
  </definitions>
  <altoutputs>
    <html>https://goldbook.iupac.org/terms/view/13009/html</html>
    <json>https://goldbook.iupac.org/terms/view/13009/json</json>
    <plain>https://goldbook.iupac.org/terms/view/13009/plain</plain>
  </altoutputs>
  <citation>Citation: 'chronic rejection' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13009</citation>
  <license>The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.</license>
  <collection>If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .</collection>
  <disclaimer>The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.</disclaimer>
  <accessed>2026-05-10T02:26:17+00:00</accessed>
</term>
