https://doi.org/10.1351/goldbook.13061
Cutaneous or systemic vasculitis caused by cold-labile proteins (cryoglobulins, cryofibrinogen) that leads to increased viscosity, protein precipitation or gelatinification, complement activation, and endothelial cell damage, especially in the cold.
Note: Frequently associated with chronic hepatitis C or B infection, but can also be induced by other infections and malignancies.