Title: cytotoxic T lymphocyte antigen 4
Long Title: IUPAC Gold Book - cytotoxic T lymphocyte antigen 4
DOI: 10.1351/goldbook.13073
Status: current

Definition
High affinity receptor for B7 molecules expressed on T cells, binding of which inhibits T cell activation.

Note
Mutations in the gene encoding CTLA-4 have been associated with various autoimmune diseases.

Related Terms
- B7 molecules: https://goldbook.iupac.org/terms/view/12933
- T cells: https://goldbook.iupac.org/terms/view/13724
- activation: https://goldbook.iupac.org/terms/view/13401
- autoimmune diseases: https://goldbook.iupac.org/terms/view/12919

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1154 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13073/html
- json: https://goldbook.iupac.org/terms/view/13073/json
- xml: https://goldbook.iupac.org/terms/view/13073/xml

Citation: Citation: 'cytotoxic T lymphocyte antigen 4' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13073
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Accessed: 2026-05-14T14:59:36+00:00