13074 IUPAC Gold Book - cytotoxic T lymphocyte assay 10.1351/goldbook.13074 13074 current initialism: CTL 1 Assay based on quantitation of cell death caused by sensitized lymphocytes or splenocytes cultured with a fixed number of tumor or other target cells that have been prelabeled with \(\ce{^{51}Cr}\). The \(\ce{^{51}Cr}\) is taken up and reversibly binds to cytosolic proteins. When these target cells are incubated with sensitized lymphocytes, the target cells are killed and the \(\ce{^{51}Cr}\) is released. lymphocytes https://goldbook.iupac.org/terms/view/13399 target cells https://goldbook.iupac.org/terms/view/13727 PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1154 (https://doi.org/10.1351/PAC-REC-11-06-03) https://goldbook.iupac.org/terms/view/13074/html https://goldbook.iupac.org/terms/view/13074/json https://goldbook.iupac.org/terms/view/13074/plain Citation: 'cytotoxic T lymphocyte assay' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13074 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-05-14T15:58:29+00:00