13085 IUPAC Gold Book - delayed-type hypersensitivity 10.1351/goldbook.13085 13085 current initialism: DTH synonym: Gell and Coombs Type IV reaction 1 Form of T cell-mediated immunity in which the ultimate effector cell is the activated mononuclear phagocyte (macrophage); the response of DTH appears fully over \(\pu{24}\) to \(\pu{48 h}\). Previous exposure is required. Examples include response to Mycobacterium tuberculosis (tuberculin test) and contact dermatitis. Response to Mycobacterium tuberculosis (tuberculin test) and contact dermatitis. T cell https://goldbook.iupac.org/terms/view/13724 contact dermatitis https://goldbook.iupac.org/terms/view/13041 immunity https://goldbook.iupac.org/terms/view/13272 macrophage https://goldbook.iupac.org/terms/view/13424 phagocyte https://goldbook.iupac.org/terms/view/13560 tuberculin test https://goldbook.iupac.org/terms/view/13758 PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1156 (https://doi.org/10.1351/PAC-REC-11-06-03) https://goldbook.iupac.org/terms/view/13085/html https://goldbook.iupac.org/terms/view/13085/json https://goldbook.iupac.org/terms/view/13085/plain Citation: 'delayed-type hypersensitivity' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13085 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-06-27T15:48:57+00:00