Title: Draize test
Long Title: IUPAC Gold Book - Draize test
DOI: 10.1351/goldbook.13104
Status: current

Definition
Context: ocular; Test for potential to cause irritation to the eye in which the test substance is applied directly to the eye of restrained rabbits.
Note: Widely criticized as unethical. Now often replaced with an acute eye irritation test using cadaveric chicken eyes.
Context: skin; Test for the potential of a material to cause irritation or corrosion following local dermal application. Generally performed with rabbits.

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1159 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13104/html
- json: https://goldbook.iupac.org/terms/view/13104/json
- xml: https://goldbook.iupac.org/terms/view/13104/xml

Citation: Citation: 'Draize test' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13104
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Accessed: 2026-07-25T16:07:23+00:00