Title: Foxp3
Long Title: IUPAC Gold Book - Foxp3
DOI: 10.1351/goldbook.13141
Status: current

Definition
Transcription repressor that is specifically expressed in CD4+CD25+ T cells.

Note
Mutations in the FOXP3 gene may lead to an autoimmune syndrome called IPEX (immunodysregulation–polyendocrinopathy–enteropathy, X-linked).

Related Terms
- CD4+CD25+ T cells: https://goldbook.iupac.org/terms/view/12974
- autoimmune: https://goldbook.iupac.org/terms/view/12918
- immunodysregulation–polyendocrinopathy–enteropathy, X-linked: https://goldbook.iupac.org/terms/view/13283

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1165 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13141/html
- json: https://goldbook.iupac.org/terms/view/13141/json
- xml: https://goldbook.iupac.org/terms/view/13141/xml

Citation: Citation: 'Foxp3' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13141
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Accessed: 2026-05-10T18:46:16+00:00