13169 IUPAC Gold Book - gene rearrangement 10.1351/goldbook.13169 13169 current 1 Structural alteration in a chromosome that changes the order of its genetic loci, occurring by DNA recombination, e.g., during development or in some cancers. In immunology, it refers to recombination of gene segments in immunoglobulin (Ig) and T-cell receptor (TCR) loci to produce a functional variable (V) region sequence. T-cell receptor (TCR) https://goldbook.iupac.org/terms/view/13714 immunology https://goldbook.iupac.org/terms/view/13303 variable (V) region https://goldbook.iupac.org/terms/view/13773 PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1169 (https://doi.org/10.1351/PAC-REC-11-06-03) https://goldbook.iupac.org/terms/view/13169/html https://goldbook.iupac.org/terms/view/13169/json https://goldbook.iupac.org/terms/view/13169/plain Citation: 'gene rearrangement' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13169 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-05-10T16:26:57+00:00