Title: granuloma
Long Title: IUPAC Gold Book - granuloma
DOI: 10.1351/goldbook.13185
Status: current

Definition
Mass or nodule of granulation tissue, with actively growing fibroblasts and capillary buds, characterized by the presence of aggregates of modified macrophages resembling epithelial cells (epithelioid histiocytes), and lymphocytes, surrounded by a rim of giant multinucleate cells, either of the Langerhans or foreign body type.

Note
Granuloma is due to a chronic inflammatory process associated with infectious disease, such as tuberculosis, syphilis, sarcoidosis, leprosy, lymphogranuloma, etc., or with invasion by a foreign body.

Related Terms
- Langerhans: https://goldbook.iupac.org/terms/view/13373
- lymphocytes: https://goldbook.iupac.org/terms/view/13399
- macrophages: https://goldbook.iupac.org/terms/view/13424
- sarcoidosis: https://goldbook.iupac.org/terms/view/13658

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1171 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13185/html
- json: https://goldbook.iupac.org/terms/view/13185/json
- xml: https://goldbook.iupac.org/terms/view/13185/xml

Citation: Citation: 'granuloma' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13185
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Accessed: 2026-05-14T08:43:53+00:00