Title: immunoglobulin superfamily
Long Title: IUPAC Gold Book - immunoglobulin superfamily
DOI: 10.1351/goldbook.13295
Status: current

Definition
Large family of proteins characterized by possession of "immunoglobulin-type" domains of approximately 110 amino acids folded into two \(\ce{\upbeta\mbox{-}pleated sheets}\). Members include immunoglobulins \(A\), \(E\), \(G\), \(M\) (IgA, IgE, IgG, and IgM), T-cell receptors (TCRs), and human leukocyte antigen (HLA) major histocompatibility complex (MHC) molecules.

Related Terms
- IgA: https://goldbook.iupac.org/terms/view/13286
- IgE: https://goldbook.iupac.org/terms/view/13288
- IgG: https://goldbook.iupac.org/terms/view/13292
- IgM: https://goldbook.iupac.org/terms/view/13293
- T-cell receptors (TCRs): https://goldbook.iupac.org/terms/view/13714
- human leukocyte antigen (HLA): https://goldbook.iupac.org/terms/view/13230
- major histocompatibility complex (MHC) molecule: https://goldbook.iupac.org/terms/view/13434

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1188 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13295/html
- json: https://goldbook.iupac.org/terms/view/13295/json
- xml: https://goldbook.iupac.org/terms/view/13295/xml

Citation: Citation: 'immunoglobulin superfamily' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13295
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Accessed: 2026-05-10T09:49:14+00:00