13295 IUPAC Gold Book - immunoglobulin superfamily 10.1351/goldbook.13295 13295 current 1 Large family of proteins characterized by possession of "immunoglobulin-type" domains of approximately 110 amino acids folded into two \(\ce{\upbeta\mbox{-}pleated sheets}\). Members include immunoglobulins \(A\), \(E\), \(G\), \(M\) (IgA, IgE, IgG, and IgM), T-cell receptors (TCRs), and human leukocyte antigen (HLA) major histocompatibility complex (MHC) molecules. IgA https://goldbook.iupac.org/terms/view/13286 IgE https://goldbook.iupac.org/terms/view/13288 IgG https://goldbook.iupac.org/terms/view/13292 IgM https://goldbook.iupac.org/terms/view/13293 T-cell receptors (TCRs) https://goldbook.iupac.org/terms/view/13714 human leukocyte antigen (HLA) https://goldbook.iupac.org/terms/view/13230 major histocompatibility complex (MHC) molecule https://goldbook.iupac.org/terms/view/13434 PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1188 (https://doi.org/10.1351/PAC-REC-11-06-03) https://goldbook.iupac.org/terms/view/13295/html https://goldbook.iupac.org/terms/view/13295/json https://goldbook.iupac.org/terms/view/13295/plain Citation: 'immunoglobulin superfamily' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13295 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-05-10T09:48:14+00:00