Title: immunologically privileged site
Long Title: IUPAC Gold Book - immunologically privileged site
DOI: 10.1351/goldbook.13299
Status: current

Definition
Any of various sites in the body where foreign tissue grafts do not induce an immune reaction.

Note
Such sites include the eye, brain, testis, and unborn fetus. Although antigens do migrate from these privileged sites, they either induce immunological tolerance or a nondestructive response.

Related Term
- immunological tolerance: https://goldbook.iupac.org/terms/view/13302

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1189 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13299/html
- json: https://goldbook.iupac.org/terms/view/13299/json
- xml: https://goldbook.iupac.org/terms/view/13299/xml

Citation: Citation: 'immunologically privileged site' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13299
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Accessed: 2026-05-10T03:58:10+00:00