{"term":{"id":"13302","title":"immunological tolerance","longtitle":"IUPAC Gold Book - immunological tolerance","doi":"10.1351\/goldbook.13302","code":"13302","status":"current","synonym":"<em>synonym<\/em>: tolerance","definitions":[{"id":1,"text":"Persistent specific immunological unresponsiveness toward a substance that would normally be expected to elicit an immune response, resulting from previous non-sensitizing exposure to an antigen.","notes":{"1":"Tolerance to specific foreign antigens can be induced by the exposure to the foreign antigens during embryonic or neonatal life (depending upon species). In adults, tolerance (usually of shorter duration) can be induced by using particular routes of administration for the antigens or administration of agents that are particularly effective against cells proliferating in response to antigen. Mechanisms may include deletion of potentially reactive lymphocytes or their \"inactivation\" by immunological suppression."},"links":[{"term":"lymphocytes","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13399"},{"term":"suppression","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13701"}],"sources":["PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1189 (https:\/\/doi.org\/10.1351\/PAC-REC-11-06-03)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/13302\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/13302\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/13302\/plain"},"citation":"Citation: 'immunological tolerance' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.13302","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-10T03:06:52+00:00"}}