https://doi.org/10.1351/goldbook.13334
Group of chronic inflammatory conditions resulting in the inappropriate and persistent activation of the mucosal immune system of the bowel.
Notes:
- Idiopathic IBD is a set of chronic conditions probably driven by the presence of normal intestinal flora.
- Autoantibodies against proteins of neutrophil granulocytes, pancreatic acinus, intestinal goblet, and colonic epithelial cells are detectable.
- Crohn disease and ulcerative colitis are two variants of IBD with overlapping clinical manifestations and probable autoimmune origins. Crohn disease is immunologically characterized by antibody to Saccharomyces cerevisiae and Th1 cell-dominated responses.