Title: major histocompatibility complex restriction
Long Title: IUPAC Gold Book - major histocompatibility complex restriction
DOI: 10.1351/goldbook.13435
Status: current

Definition
Necessity that T cells recognize processed antigen only when presented by major histocompatibility complex (MHC) molecules of the original haplotype associated with T-cell priming.

Related Terms
- T cells: https://goldbook.iupac.org/terms/view/13724
- haplotype: https://goldbook.iupac.org/terms/view/13193
- major histocompatibility complex (MHC) molecules: https://goldbook.iupac.org/terms/view/13434
- priming: https://goldbook.iupac.org/terms/view/13607

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1209 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13435/html
- json: https://goldbook.iupac.org/terms/view/13435/json
- xml: https://goldbook.iupac.org/terms/view/13435/xml

Citation: Citation: 'major histocompatibility complex restriction' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13435
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Accessed: 2026-06-27T20:44:27+00:00