{"term":{"id":"13465","title":"mixed connective tissue disease","longtitle":"IUPAC Gold Book - mixed connective tissue disease","doi":"10.1351\/goldbook.13465","code":"13465","status":"current","initialism":"<em>initialism<\/em>: MCTD","synonym":"<em>synonym<\/em>: Sharp’s syndrome","definitions":[{"id":1,"text":"Human autoimmune disease in which the immune system attacks the body, producing symptoms that combine features of polymyositis, systemic lupus erythematosus (SLE), and systemic scleroderma, and thus being considered as an overlap syndrome.","notes":{"1":"MCTD commonly causes joint pain\/swelling, Raynaud phenomenon, muscle inflammation, and scarring of the skin of the hand. It does not typically cause kidney disease or seizures.","2":"Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody (ANA) and an anti-U1-RNP antibody."},"links":[{"term":"Raynaud phenomenon","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13632"},{"term":"anti-nuclear antibody (ANA)","url":"https:\/\/goldbook.iupac.org\/terms\/view\/12898"},{"term":"autoimmune disease","url":"https:\/\/goldbook.iupac.org\/terms\/view\/12919"},{"term":"immune system","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13271"},{"term":"scleroderma","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13660"},{"term":"systemic","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13708"},{"term":"systemic lupus erythematosus (SLE)","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13710"}],"sources":["PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1213 (https:\/\/doi.org\/10.1351\/PAC-REC-11-06-03)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/13465\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/13465\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/13465\/plain"},"citation":"Citation: 'mixed connective tissue disease' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.13465","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-10T05:58:35+00:00"}}