https://doi.org/10.1351/goldbook.13488
Enzyme found in azurophilic granules of neutrophils, the major target of antineutrophil cytoplasmic autoantibody (ANCA).
Notes:
- MPO autoantibodies are diagnostic markers for microscopic polyangiitis, rapidly progressive glomerulonephritis, and Goodpasture disease or syndrome.
- MPO autoantibodies are also found in patients exposed to silica or drugs (e.g., hydralazine, propylthiouracil, D-penicillamine) as well as in some patients with Wegener granulomatosis (WG) and other autoimmune diseases.