Title: NACHT domain-, leucine-rich repeat (LRR)-, and pyrin (N-terminal homology) domain (PYD)-containing protein 3
Long Title: IUPAC Gold Book - NACHT domain-, leucine-rich repeat (LRR)-, and pyrin (N-terminal homology) domain (PYD)-containing protein 3
DOI: 10.1351/goldbook.13492
Status: current

Definition
NOD-like receptor (NLR), found in certain inflammasomes, that binds to aggregated proteins and the peptides that compose them. Its activation leads to the generation of inflammatory cytokines, such as interleukin (IL)-1, and neurotoxic factors.

Note
Mutations in NALP3 are responsible for the autoinflammatory diseases familial cold autoinflammatory syndrome, Muckle–Wells syndrome and neonatal onset multisystem inflammatory disease.

Related Terms
- NOD-like receptor (NLR): https://goldbook.iupac.org/terms/view/13494
- cytokines: https://goldbook.iupac.org/terms/view/13065
- inflammasomes: https://goldbook.iupac.org/terms/view/13333
- interleukin (IL): https://goldbook.iupac.org/terms/view/13338

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1218 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13492/html
- json: https://goldbook.iupac.org/terms/view/13492/json
- xml: https://goldbook.iupac.org/terms/view/13492/xml

Citation: Citation: 'NACHT domain-, leucine-rich repeat (LRR)-, and pyrin (N-terminal homology) domain (PYD)-containing protein 3' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13492
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Accessed: 2026-05-11T00:23:43+00:00