Title: peptide-binding groove
Long Title: IUPAC Gold Book - peptide-binding groove
DOI: 10.1351/goldbook.13548
Status: current

Definition
Structural feature found in major histocompatibility complex (MHC) class I and class II heterodimeric proteins that can bind endogenous peptides.

Related Terms
- antigen-presenting groove: https://goldbook.iupac.org/terms/view/12889
- class II: https://goldbook.iupac.org/terms/view/13432
- major histocompatibility complex (MHC) class I: https://goldbook.iupac.org/terms/view/13431

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1226 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13548/html
- json: https://goldbook.iupac.org/terms/view/13548/json
- xml: https://goldbook.iupac.org/terms/view/13548/xml

Citation: Citation: 'peptide-binding groove' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13548
License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.
Collection: If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .
Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-06-30T03:32:40+00:00